Bryan Trevor Sewell

Bryan Trevor Sewell

Programme Director

Programme Director

Prof Trevor Sewell (Centre for Imaging and Analysis) is Director of the Electron Microscope Unit (an inter-faculty and regional resource centre) and also has experience in computer-based education. He is actively engaged in research in the field of structural biology. In addition to his co-ordinating role, Prof Sewell will present lectures on the determination of the three-dimensional structures of cells using tomography and single particle methods for the determination of macromolecular structure. He will also present workshops explaining some of the major achievements of structural biology studies on large structures including the ribosome.

Contact Details

Phone: (021) 650 2817 • Email: az.ca.tcunull@llewes.rovert
Physical address: Room 1.01, New Engineering Building, 55 Madiba Circle, Upper Campus, UCT, Rondebosch

Current Projects

The structure, mechanism and specificity of amidases. .


Publications

Journal Articles

Crum, MA, JM Park, BT Sewell, and MJ Benedik. 2015. "C-terminal hybrid mutant of Bacillus pumilus cyanide dihydratase dramatically enhances thermal stability and pH tolerance by reinforcing oligomerization." Journal of Applied Microbiology, 118 (4): 881-889.

Crum, MA, JM Park, AE Mulelu, BT Sewell, and MJ Benedik. 2015. "Probing C-terminal interactions of the Pseudomonas stutzeri cyanide-degrading CynD protein." Applied Microbiology and Biotechnology, 99 (7): 3093-3102.

Ambele, MA, BT Sewell, FR Cummings, PJ Smith, and TJ Egan. 2013. "Synthetic hemozoin (beta-hematin) crystals nucleate at the surface of neutral lipid droplets that control their sizes." Crystal Growth & Design, 13 (10).

Weber, BW, SW Kimani, A Varsani, DA Cowan, R Hunter, GA Venter, JC Gumbart, and BT Sewell. 2013. "The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning." Journal of Biological Chemistry, 288 (40): 28514-28523.

Baum, S, DS Williamson, T Sewell, and A Stolz. 2012. "Conversion of sterically demanding alpha,alpha-disubstituted phenylacetonitriles by the arylacetonitrilase from Pseudomonas fluorescens EBC191." Applied and Environmental Microbiology, 78 (1): 48-57.

Broadley, SG, JC Gumbart, BW Weber, MJ Marakalala, DJ Steenkamp, and BT Sewell. 2012. "A new crystal form of MshB from Mycobacterium tuberculosis with glycerol and acetate in the active site suggests the catalytic mechanism." Acta Crystallographica. Section D, Biological crystallography, 68 (Pt 11): 1450-1459.

Manole, V, P Laurinmaki, W Van Wyngaardt, CA Potgieter, IM Wright, GJ Venter, AA van Dijk, BT Sewell, and SJ Butcher. 2012. "Structural insight into African horsesickness virus infection." Journal of Virology, 86 (15): 7858-7866.

Twala, BV, BT Sewell, and J Jordaan. 2012. "Immobilisation and characterisation of biocatalytic co-factor recycling enzymes, glucose dehydrogenase and NADH oxidase, on aldehyde functional ReSyn™ polymer microspheres." Enzyme and Microbial Technology, 50 (6-7): 331-336.

Wang, L, JM Watermeyer, AE Mulelu, BT Sewell, and MJ Benedik. 2012. "Engineering pH-tolerant mutants of a cyanide dihydratase." Applied Microbiology and Biotechnology, 94 (1): 131-140.

Chan, KY, J Gumbart, R McGreevy, JM Watermeyer, BT Sewell, and K Schulten. 2011. "Symmetry-restrained flexible fitting for symmetric EM maps." Structure (London, England: 1993), 19 (9): 1211-1218.

Miller, JL, J Woodward, S Chen, M Jaffer, B Weber, K Nagasaki, Y Tomaru, R Wepf, A Roseman, A Varsani, and T Sewell. 2011. "Three-dimensional reconstruction of Heterocapsa circularisquama RNA virus by electron cryo-microscopy." Journal of General Virology, 92 (8): 1960-1970.

Nel, AJM, IM Tuffin, BT Sewell, and DA Cowan. 2011. "Unique aliphatic amidase from a psychrotrophic and haloalkaliphilic nesterenkonia isolate." Applied and Environmental Microbiology, 77 (11): 3696-3702.

van Rooyen, JM, VR Abratt, H Belrhali, and T Sewell. 2011. "Crystal structure of Type III glutamine synthetase: surprising reversal of the inter-ring interface." Structure (London, England: 1993), 19 (4): 471-483.

van Rooyen, J, H Belrhali, V Abratt, and BT Sewell. 2011. "Proteolysis of the type III glutamine synthetase from Bacteroides fragilis causes expedient crystal-packing rearrangements." Acta Crystallographica. Section F, Structural biology and crystallization communications, 67 (Pt 3): 358-363.

Achilonu, I, S Gildenhuys, L Fisher, J Burke, S Fanucchi, BT Sewell, M Fernandes, and HW Dirr. 2010. "The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function." Acta Crystallographica. Section F, Structural biology and crystallization communications, 66 (Pt 7): 776-780.

Gildenhuys, S, M Dobreva, N Kinsley, Y Sayed, J Burke, S Pelly, GP Gordon, M Sayed, BT Sewell, and HW Dirr. 2010. "Arginine 15 stabilizes an S(N)Ar reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1." Biophysical Chemistry, 146 (2-3): 118-125.

Joubert, MK, N Kinsley, A Capovilla, BT Sewell, MS Jaffer, and M Khati. 2010. "A modeled structure of an aptamer-gp120 complex provides insight into the mechanism of HIV-1 neutralization." Biochemistry, 49 (28): 5880-5890.

Opperman, DJ, BT Sewell, D Litthauer, MN Isupov, JA Littlechild, and E van Heerden. 2010. "Crystal structure of a thermostable old yellow enzyme from Thermus scotoductus SA-01." Biochemical and Biophysical Research Communications, 393 (3): 426-431.

Petersen, LN, S Marineo, S Mandala, F Davids, BT Sewell, and RA Ingle. 2010. "The missing link in plant histidine biosynthesis: Arabidopsis myoinositol monophosphatase-like2 encodes a functional histidinol-phosphate phosphatase." Plant Physiology, 152 (3): 1186-1196.

van Rooyen, JM, VR Abratt, H Belrhali, and BT Sewell. 2010. "Crystallization of recombinant Bacteroides fragilis glutamine synthetase (GlnN) isolated using a novel and rapid purification protocol." Protein expression and purification, 74 (2): 211-216.

Watermeyer, JM, WL Kroger, HG O Neill, BT Sewell, and ED Sturrock. 2010. "Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril." Biochemical Journal, 428 (1): 67-74.

Williamson, DS, KC Dent, BW Weber, A Varsani, J Frederick, RN Thuku, RA Cameron, JH van Heerden, DA Cowan, and BT Sewell. 2010. "Structural and biochemical characterization of a nitrilase from the thermophilic bacterium, Geobacillus pallidus RAPc8." Applied Microbiology and Biotechnology, 88 (1): 143-153.

Woodward, JD and BT Sewell. 2010. "Tomography of asymmetric bulk specimens imaged by scanning electron microscopy." Ultramicroscopy, 110 (2): 170-175.

Dent, KC, BW Weber, MJ Benedik, and BT Sewell. 2009. "The cyanide hydratase from Neurospora crassa forms a helix which has a dimeric repeat." Applied Microbiology and Biotechnology, 82 (2): 271-278.

Frouws, TD, HG Patterton, and BT Sewell. 2009. "Histone octamer helical tubes suggest that an internucleosomal four-helix bundle stabilizes the chromatin fiber." Biophysical Journal, 96 (8): 3363-3371.

Thuku, RN, D Brady, MJ Benedik, and BT Sewell. 2009. "Microbial nitrilases: versatile, spiral forming, industrial enzymes." Journal of Applied Microbiology, 106 (3): 703-727.

Woodward, JD, R Wepf, and BT Sewell. 2009. "Three-dimensional reconstruction of biological macromolecular complexes from in-lens scanning electron micrographs." Journal of Microscopy, 234 (3): 287-292.

Basile, LJ, RC Wilson, and BT Sewell. 2008. "Genome mining of cyanide-degrading nitrilases from filamentous fungi." Applied Microbiology and Biotechnology, 80 (3): 427-435.

Watermeyer, JM, WL Kroger, HG O Neill, BT Sewell, and ED Sturrock. 2008. "Probing the basis of domain-dependent inhibition using novel ketone inhibitors of angiotensin-converting enzyme." Biochemistry, 47 (22): 5942-5950.

Woodward, JD, BW Weber, MP Scheffer, MJ Benedik, A Hoenger, and BT Sewell. 2008. "Helical structure of unidirectionally shadowed metal replicas of cyanide hydratase from Gloeocercospora sorghi." Journal of Structural Biology, 161 (2): 111-119.

Corradi, HR, I Chitapi, BT Sewell, D Georgiadis, V Dive, ED Sturrock, and KR Acharya. 2007. "The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380." Biochemistry, 46 (18): 5473-5478.

Kimani, SW, VB Agarkar, DA Cowan, MFR Sayed, and BT Sewell. 2007. "Structure of an aliphatic amidase from Geobacillus pallidus RAPc8." Acta Crystallographica. Section D, Biological Crystallography, 63 (Pt 10): 1048-1058.

Makhongela, HS, AE Glowacka, VB Agarkar, BT Sewell, B Weber, RA Cameron, DA Cowan, and SG Burton. 2007. "A novel thermostable nitrilase superfamily amidase from Geobacillus pallidus showing acyl transfer activity." Applied Microbiology and Biotechnology, 75 (4): 801-811.

Thuku, RN, BW Weber, A Varsani, and BT Sewell. 2007. "Post-translational cleavage of recombinantly expressed nitrilase from Rhodococcus rhodochrous J1 yields a stable, active helical form." FEBS Journal, 274 (8): 2099-2108.

Agarkar, VB, SW Kimani, DA Cowan, MFR Sayed, and BT Sewell. 2006. "The quaternary structure of the amidase from Geobacillus pallidus RAPc8 is revealed by its crystal packing." Acta crystallographica. Section F, Structural biology and crystallization communications, 62 (Pt 12): 1174-1178.

Tastan Bishop, AO and T Sewell. 2006. "A new approach to possible substrate binding mechanisms for nitrile hydratase." Biochemical and Biophysical Research Communications, 343 (1): 319-325.

van Rooyen, JM, VR Abratt, and BT Sewell. 2006. "Three-dimensional structure of a type III glutamine synthetase by single-particle reconstruction." Journal of Molecular Biology, 361 (4): 796-810.

Watermeyer, JM, BT Sewell, SL Schwager, R Natesh, HR Corradi, KR Acharya, and ED Sturrock. 2006. "Structure of testis ACE glycosylation mutants and evidence for conserved domain movement." Biochemistry, 45 (42): 12654-12663.

Jandhyala, DM, RC Willson, BT Sewell, and MJ Benedik. 2005. "Comparison of cyanide-degrading nitrilases." Applied Microbiology and Biotechnology, 68 (3): 327-335.

Kuhnert, DC, Y Sayed, S Mosebi, M Sayed, BT Sewell, and HW Dirr. 2005. "Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study." Journal of Molecular Biology, 349 (4): 825-838.

Sewell, BT, RN Thuku, X Zhang, and MJ Benedik. 2005. "Oligomeric structure of nitrilases: effect of mutating interfacial residues on activity." Annals of the New York Academy of Sciences, 1056, 153-159.

Sewell, BT, RB Best, S Baum, AM Roseman, GW Farr, AL Horwich, and HR Saibil. 2004. "A mutant chaperonin with rearranged inter-ring electrostatic contacts and temperature-sensitive dissociation." Nature Structural & Molecular Biology, 11 (11): 1128-1133.

Tsekoa, TL, MF Sayed, RA Cameron, BT Sewell, and DA Cowan. 2004. "Purification, crystallization and preliminary X-ray diffraction analysis of thermostable nitrile hydratase." South African Journal of Science, 100 (9-10): 488-491.

Jandhyala, D, M Berman, PR Meyers, BT Sewell, RC Willson, and MJ Benedik. 2003. "CynD, the cyanide dihydratase from Bacillus pumilus: gene cloning and structural studies." Applied and Environmental Microbiology, 39 (8): 4794-4805.

Sewell, BT, MN Berman, PR Meyers, D Jandhyala, and MJ Benedik. 2003. "The cyanide degrading nitrilase from Pseudomonas stutzeri AK61 is a two-fold symmetric, 14-subunit spiral." Structure (London, England: 1993), 11 (11): 1413-1422.

Egan, TJ, JM Combrinck, J Egan, GR Hearne, HM Marques, S Ntenteni, BT Sewell, PJ Smith, D Taylor, DA van Schalkwyk, and JC Walden. 2002. "Fate of haem iron in the malaria parasite Plasmodium falciparum." Biochemical Journal, 362 (Pt 2): 343-347.

Kirsch, R, MA Jaffer, BE Woodburne, T Sewell, SL Kelly, RE Kirsch, and EG Shephard. 2002. "Fibrinogen is degraded and internalized during incubation with neutrophils, and fibrinogen products localize to electron lucent vesicles." Biochemical Journal, 364 (Pt 2): 403-412.

Nicolls, FC, G de Jager, and BT Sewell. 1997. "Use of a general imaging model to achieve predictive autofocus in the scanning electron microscope." Ultramicroscopy, 69 (1): 25-37.

Delpierre, GR and BT Sewell. 1995. "Designing for the real world: physical science courseware for South African schools." Spectrum, 33 (4): 18-20.

Parthasarathy, M, P Garcia-Lario, D de Martino, SR Pottasch, D Kilkenny, P Martinez, KC Sahu, BE Reddy, and BT Sewell. 1995. "Fading and variations in the spectrum of the central star of the very young planetary nebula SAO 244567 (Hen 1357)." Astronomy and Astrophysics, 300.

Sewell, BT and GR Delpierre. 1992. "Using computers to integrate, consolidate and improve biochemical education." Biochemical Education, 20 (1): 14-17.

Blundell, TL, JA Jenkins, BT Sewell, LH Pearl, JB Cooper, IJ Tickle, B Veerapandian, and SP Wood. 1990. "X-ray analyses of aspartic proteinases. The three-dimensional structure at 2.1 A resolution of endothiapepsin." Journal of Molecular Biology, 211 (4): 919-941.

Lawrence, MC, MA Jaffer, and BT Sewell. 1989. "The application of the maximum entropy method to electron microscopic tomography." Ultramicroscopy, 31 (3): 285-301.

von Holt, C, WF Brandt, HJ Greyling, GG Lindsey, JD Retief, JD Rodrigues, S Schwager, and BT Sewell. 1989. "Isolation and characterization of histones." Methods in Enzymology, 170, 431-523.

Greyling, HJ, BT Sewell, and C Von Holt. 1988. "The reconstitution of a hybrid histone octamer containing avian 110Cys-des-thio-histone H3 and sea-urchin 73Cys-histone H4." European Journal of Biochemistry, 171 (3): 721-726.

Landsman, D, BT Sewell, and C von Holt. 1988. "Aberrant DNase I digestion kinetics of nucleosomal core particles from sea urchin sperm." Biochemical and Biophysical Research Communications, 155 (1): 66-73.

Retief, JD, bt Sewell, and C Von Holt. 1987. "Nucleosome cores assembled in vitro occupy two preferred frames flanking the histone H1 gene from Psammechinus miliaris." Biochemistry, 26 (14): 4449-4453.

Brandt, WF, BT Sewell, and C von Holt. 1986. "Mr determination of histones from their electrophoretic mobility in acidic urea gels in the absence of detergents." FEBS Letters, 194 (2): 273-277.

Greyling, HJ, JP Hapgood, BT Sewell, and C von Holt. 1986. "Covalent labelling of histones with aurothiomalate. Gold-labelled H2A-H2B dimers assemble to octamers, which form crystalline helical tubes." European Journal of Biochemistry, 161 (1): 133-138.

Retief, JD, BT Sewell, HJ Greyling, S Schwager, and C von Holt. 1984. "Probing with DNase I of nucleosomal core particles assembled in vitro in the presence of polyglutamic acid." FEBS letters, 167 (1): 170-175.

Sewell, BT, C Bouloukos, and C von Holt. 1984. "Formaldehyde and glutaraldehyde in the fixation of chromatin for electron microscopy." Journal of Microscopy, 136 (Pt 1): 103-112.

Greyling, HJ, S Schwager, BT Sewell, and C von Holt. 1983. "The identity of conformational states of reconstituted and native histone octamers." European Journal of Biochemistry, 137 (1-2): 221-226.

Sewell, BT. 1982. "A rapid lookup table method for trigonometric functions." Software: Practice and Experience, 12 (10): 885-887.

Blundell, TL, BT Sewell, and AD McLachlan. 1979. "Four-fold structural repeat in the acid proteases.".

Books

Sewell, BT, GR Delpierre, and RC Lippert. 1993. "The CAI experience at UCT." In Computer-Based Education and Training in South Africa,, 51-66. Pretoria, South Africa: J.L. van Schaik Publishers.

Blundell, TL, J Jenkins, L Pearl, and BT Sewell. 1985. "The high resolution structure of endothiapepsin." In Aspartic Proteinases and their Inhibitors, edited by V Kostka, Berlin: Walter de Gruyter and Co.

Blundell, TL, J Jenkins, L Pearl, BT Sewell, and V Kostka. 1985. "The high resolution structure of Endothiapepsin in Aspartic Proteinases and their Inhibitors." Berlin.

Blundell, TL, T Sewell, W Turnell, G Dodson, JP Glusker, and D Sayre. 1981. "Symmetry in the structure and organization of proteins." In Structural Studies on Molecules of Biological Interest: A Volume in Honour of Professor Dorothy Hodgkin,, 390-403. Oxford, UK: Clarendon Press.

Blundell, TL, HB Jones, G Kahn, LH Pearl, T Sewell, G Taylor, and SP Wood. 1980. "The active site of acid proteinases." In Enzyme Regulation and Mechanisms of Action, edited by P Mildner and B Ries, 281-288. Oxford, UK: Pergamon Press Ltd.

Blundell, TL, T Sewell, JA Jenkins, IJ Tickle, C Slingsby, DS Moss, PF Lindley, WG Turnell, G Wistow, and R Srinivasan. 1979. "Structural evidence for gene duplication and fusion in proteins." In Biomolecular Structure, Conformation, Function and Evolution,, 251-256. Oxford, UK: Pergamon Press Ltd.

Blundell, TL, JA Jenkins, G Kahn, P Chowdhury, T Sewell, IJ Tickle, and EA Wood. 1979. "The three dimensional structure of acid proteinases." In Protein: Structure, Function and Industrial Applications, edited by E Hofmann, W Pfeil, and H Aurich, 81-94. Proceedings of the 12th FEBS meeting.

Blundell, TL, S Bedarkar, SP Wood, and T Sewell. 1977. "The evolution of the metal binding sites in proteins: Zinc binding of insulin and homologous proteins." In The Evolution of Metalloenzymes, Metalloproteins and Related Materials, edited by GJ Leigh, 1-16. London, UK: Symposium Press.

Jenkins, J, I Tickle, L Tickle, A Wollmer, T Sewell, and T Blundell. 1977. "X-ray analysis and circular dichroism of the acid proteases from Endothia Parasitica and Chymosin." In The Acid Proteases, edited by J Tang, 43-60. New York, USA: Plenum.

Conferences and presentations

Sewell, BT. 2007. "A national programme in structural biology." DST 2007.

Sewell, BT. 2007. "Sorghi summary.".

Sewell, BT. 2007. "The South African Structural Biology Initiative.".

Sewell, BT. 2007. "What are the connections between the helical interfaces and the active site in the nitrilases? Insights from the structure of the amidase from Geobacillus pallidus." GRC 2007.

Sewell, BT. 2007. "Why study nitrilases?".

Thuku, RN and BT Sewell. 2007. "The helical structure of the nitrilase from Rhodococcus rhodochrous J1 following a truncation in its C-terminus." Paper presented at SPIDER Workshop.

Watermeyer, J and BT Sewell. 2007. "Domain-selective ACE inhibitors caught in the act.".

Frederick, J, D Brady, and BT Sewell. 2006. "Enzymes: new tools for synthetic chemistry." Paper presented at 1st African Structural Biology Conference. 24-27 October 2006. Wilderness, South Africa.

Thuku, RN and BT Sewell. 2006. "The formation of helical oligomers in the nitrilase from Rhodococcus rhodochrous J1 following truncations in the C-terminal." Paper presented at 1st African Structural Biology Conference. 24-27 October 2006. Wilderness, South Africa.

Woodward, JD, B Weber, M Scheffer, MJ Benedik, and BT Sewell. 2006. "Three-dimensional reconstruction of unidirectionally shadowed metal replicas of cyanide hydratase from Gloeocercospora sorghi." Paper presented at 1st African Structural Biology Conference. 24-27 October 2006. Wilderness, South Africa.

Sewell, B. 2005. "Three dimensional electron microscopic imaging of chromatin." Paper presented at SA Biochemical Society Ninth Congress. 2005. Wilderness, South Africa.

Thuku, RN and BT Sewell. 2005. "The quaternary structure of Rhodococcus rhodochrous J1 nitrilase as revealed by negative staining." Paper presented at 44th Annual Meeting of the Microscopy Society of Southern Africa. 5–7 December 2005. Pietermaritzburg, South Africa. Proc Microsc Soc S Afr, 35: 31.

van Rooyen, JM, VR Abratt, and BT Sewell. 2005. "Three-dimensional structure of a type III glutamine synthetase by single-particle reconstruction." Paper presented at 19th SASBMB Conference. 16-29 January 2005. Stellenbosch, South Africa. Proc S Afr Soc Biomol Molec Biol.

Sewell, B and M Jaffer. 2001. "Failure of a simple model to account for the iridescent colours of woodhoopoes." Paper presented at Annual Meeting of the Electron Microscopy Society of South Africa. 2001. Johannesburg, South Africa. Proc Microsc Soc S Afr, 31: 82.

Buirski-Burger, N and BT Sewell. 1998. "Can computer based education save science education in South Africa." Paper presented at Proc SAARMSE. 439-445.

Nicolls, F, G de Jager, and BT Sewell. 1996. "A predictive autofocus algorithm for SEM." Paper presented at Annual Meeting of the Microscopy Society of Southern Africa. 1996. Durban, South Africa. Proc Microsc Soc S Afr, 26: 5.

Jaffer, MA and BT Sewell. 1995. "Is a slow-scan CCD camera a viable alternative to film?" Paper presented at Proc Electron Microsc Soc S Afr. 6.

Lipinski, MR, MD Durholtz, ME Waldron, Oosthuizen, J Erasmus, and BT Sewell. 1995. "The visualisation of growth increments." Paper presented at Proc Electron Microsc Soc S Afr. 72.

Sewell, BT, VH Gartz, and HE Frimmel. 1995. "The technique of cathodoluminescence applied to Witwatersrand quartz using a Leica S440 and Oxford MonoCL." Paper presented at Proc Electron Microsc Soc S Afr. 5.

Gerneke, DA and BT Sewell. 1994. "SEM and the digital paradigm - blessing or curse?" Paper presented at Proc Electron Microsc Soc S Afr. 12.

Knutsen, RD, BT Sewell, and DA Gerneke. 1994. "Electron backscatter diffraction analysis for microtexture determination." Paper presented at Proc Electron Microsc Soc S Afr. 15.

Nicolls, FC, G de Jager, and BT Sewell. 1994. "Towards a predictive autofocus algorithm for SEM." Paper presented at Annual Meeting of the Electron Microscopy Society of South Africa. 1994. Proc Electron Microsc Soc South Afr, 24: 11.

Sewell, BT. 1993. "The three-dimensional structure of isolated chromatin fibres." Paper presented at Proc Electron Microsc Soc S Afr. 43.

Graham, M, MA Jaffer, MF Calitz, and BT Sewell. 1992. "The diameter of chromatin fibres in sections of cell nuclei." Paper presented at Proc Microsc Soc S Afr. 137-138.

Warren, R, C Von Holt, and BT Sewell. 1992. "Investigating the structure of material found in the Rancho La Brea Tar Pits, Los Angeles." Paper presented at Proc Electron Microsc Soc S Afr. 19-20.

Jaffer, MA, M Graham, and BT Sewell. 1990. "Measurement of the diameters of chromatin fibres from chicken erythrocyte and sea urchin sperm." 185-186.

Jaffer, MA, M Graham, and BT Sewell. 1990. "The interpretation of stain density maps of chromatin fibres obtained by electron microscopic tomography." Paper presented at Annual Meeting of the Electron Microscopy Society of Southern Africa. 1990. 151-152. Proc Electron Microsc Soc S Afr.

Sewell, B and MC Lawrence. 1986. "The structure of the chromatin fibre in sea urchin sperm." Paper presented at Annual Meeting of the Electron Microscopy Society of SA Conference. 1986. Proc Electron Microsc Soc S Afr, 16: 49-50.

Lawson, T, B Sewell, and C Von Holt. 1984. "Measurement of nucleosome spacer lengths from dark field electron micrographs." Paper presented at Annual Meeting of the Electron Microscopy Society of South Africa. 1984. Stellenbosch, South Africa. Proc Electron Microsc Soc S Afr, 14: 73-74.

Saffer, S and B Sewell. 1975. "A fibrous supporting structure in the human erythrocyte membrane." Paper presented at Annual Meeting of the Electron Microscopy Society of South Africa. 1975. Proc Electron Microsc Soc South Afr, 5: 23-24.

Sewell, B. 1974. "A new theory for the structure of the human erythrocyte membrane." Paper presented at Annual Meeting of the Electron Microscopy Society of South Africa. 1974. Proc Electron Microsc Soc S Afr, 4: 17-18.

Sewell, BT. "A personal view of structural biology in South Africa." University of Pretoria.

Other publications

Sewell, BT. 2005. "Treasure from the molecules of life." 2 (1): 30-33.

Delpierre, GR and BT Sewell. 2003. "A new web-based physical science resource for South African schools." Science in Africa, 2003.

Sewell, BT. 1996. "Learning science - the future is here!" 38, 34-35.