Cells and the Fabric of Life

Cells and the Fabric of Life

Syllabus

  1. Embryonic origin of tissues
  2. Differentiation and Histiogenesis
    1. Paradigm of differential gene expression
  3. Epithelia
    1. Classification of epithelia, types
    2. Structure and function of basement membranes
    3. Cell surface specializations
    4. Cell junction
    5. Glands and glandula epithelia
  4. Muscle tissues
    1. Organization of skeletal muscle
    2. Innervation, end plates, T-tubule system contraction
    3. Histiogenesis of muscle
    4. Cardiac muscle
    5. Smooth muscle
  5. Evolution of multicellarity
  6. Immune system
  7. Connective tissues
    1. Cells and fibres, classification
    2. Collagen structure
    3. Adipose tissue
    4. Dermis, tendons and ligaments
    5. Cartilage
    6. Bone lamellar, compact
      1. Formation
      2. Endochandial intramembranes
      3. Maintenance and turnover
      4. Bone repair
  8. Respiratory system
  9. Female reproductive system

Online Lectures

Tutorials

  1. Early embryogenesis
  2. Differentiation & histiogenesis
  3. Epithelia
  4. Muscle tissues
  5. Evolution of multicellarity
  6. Immune system
  7. Connective tissues – soft tissue and cartilage
  8. Connective tissues – bone
  9. Respiratory system
  10. Female reproductive system

Practicals

  1. Embryos and tissues
  2. Epithelia and muscle
  3. Immune system
  4. Connective tissues
  5. Reproductive system

Assessment

  • Lab book
  • Tutorial presentation
  • Test theory and prac
  • Exam: end of year – theory and practical

References

Donnert, G, J Keller, R Medda, MA Andrei, SO Rizzoli, R Luhrmann, R Jahn, C Eggeling, and SW Hell. 2006. "Macromolecular-scale resolution in biological fluorescence microscopy." Proceedings of the National Academy of Sciences of the United States of America, 103 (31): 11440-11445.

Golub, T, S Wacha, and P Caroni. 2004. "Spatial and temporal control of signaling through lipid rafts." Current Opinion in Neurobiology, 14 (5): 542-550.

Hell, SW. 2007. "Far-field optical nanoscopy." Science (New York, N.Y.), 316 (5828): 1153-1158.

Jaiswal, JK and SM Simon. 2007. "Imaging single events at the cell membrane." Nature Chemical Biology, 3 (2): 92-98.

Kittel, RJ, C Wichmann, TM Rasse, W Fouquet, M Schmidt, A Schmid, DA Wagh, C Pawlu, RR Kellner, KI Willig, SW Hell, E Buchner, M Heckmann, and SJ Sigrist. 2006. "Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release." Science (New York, N.Y.), 312 (5776): 1051-1054.

Lagerholm, BC, GE Weinreb, K Jacobson, and NL Thompson. 2005. "Detecting microdomains in intact cell membranes." Annual Review of Physical Chemistry, 56, 309-336.

Munro, S. 2003. "Lipid rafts: elusive or illusive?" Cell, 115 (4): 377-388.

Wen, Z and JQ Zheng. 2006. "Directional guidance of nerve growth cones." Current Opinion in Neurobiology, 16 (1): 52-58.

Willig, KI, SO Rizzoli, V Westphal, R Jahn, and SW Hell. 2006. "STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis." Nature, 440 (7086): 935-939.