Structural Biology Coursework Modules

Coursework modules

Previous years’ coursework modules consisted of the following:

• Pre-requisite courses:
  • {GRD}
• Main coursework modules:
  1. {CMP}
  2. {MBBP}
  3. Supervised self-study: {PPS}
     1. Principles of Protein Structure web course
  4. {PEP}
  5. {SCB}
     3. Confocal Microscopy
  6. Technique 1:  {SBI} and {MM}
  7. Technique 2: {PC}
     2. Protein Crystallography web course
  8. Technique 3: {NMR}
  9. Technique 4: {3DEM}
  10. {APP}
      1. Post-Genome Challenge: {SDD}
      2. and
      3. {VCP}
      4. : Structural basis of ion transport through membranes {PMM}

Compulsory reading

Computational and Mathematical Primer

• Hahn BD Essential MATLAB for Scientists and Engineers (2nd Ed) Butterworth Heinemann.

Principles of Protein Structure

• Web course located at http://sbru.salamanderthemes.net/online_content/pps01_uct/course/index.html
• Brandon and Tooze

Structural Cell Biology

• Pollard TD, Earnshaw WC and Lippincott-Schwartz J (2007) Cell Biology (Second Edition), Saunders
• Medalia O, Weber I, Frangakis AS, Nicastro D, Gerisch G, Baumeister W (2002) Macromolecular Architecture in Eukaryotic Cells Visualized by Cryoelectron Tomography. Science 298, 1209-1213

Structural Bioinformatics and Molecular Modelling

• Bourne P and Weissig H (Eds.) (2003) Structural Bioinformatics. Wiley
• Leach AR (2001) Molecular Modelling – Principles and Applications (2nd edition). Pearson Education

X-ray crystallography of proteins

• Web course located at http://sbru.salamanderthemes.net/online_content/MSD-UCT/xtalindx.htm
• Blow DM (2002) Outline of Crystallography for Biologists, Oxford University Press, Oxford

Protein Nuclear Magnetic Resonance spectroscopy

• Levitt MH (2001) Spin Dynamics: Basics of Nuclear Magnetic Resonance, Wiley, Chichester

Three-dimensional Electron Microscopy

• Frank J (2006) Three-dimensional electron microscopy of macromolecular assemblies: Visualization of Biological Molecules in their native state, Oxford University Press, Oxford

Applications of Structural Biology

• Thiel KA (2004) Structure-aided drug design’s next generation. Nature Biotechnology 22, 513-519.
• Kubinyi H (1998) Structure-based design of enzyme inhibitors and receptor ligands. Current Opinion in Drug Discovery and Development 1, 4-15
• Flower RJ (2003) The development of COX2 inhibitors. Nature Reviews Drug Discovery 2, 179-191.
• Hajduk PJ, and Greer J (2007) A decade of fragment-based drug design: strategic advances and lessons learned. Nature Reviews Drug Discovery 6(3), 211-219.